KEGG pathway analysis identified the top six important KEGG pathways of the up- and down-regulated DEGs (Table 1), including ECM–receptor interaction, Wnt signalling pathway, transforming growth factor-beta (TGFβ) signalling pathway, primary immunodeficiency, hematopoietic cell lineage, and cytokine–cytokine receptor interaction. This evidence concerns the gene MMRN1 and inborn error of immunity.