FMR1 and fragile X-associated tremor/ataxia syndrome: Also, repeat-associated non-AUG (RAN) translation of the CGG repeat into polypeptides, the predominant species being poly-Glycine (FMRpolyG peptides), could contribute to FXTAS pathogenesis.60, 61 Both FMR1 mRNA and FMRpolyG peptide have been found in the human postmortem brain inclusions that are characteristic of FXTAS pathology, suggesting that both mechanisms may contribute to the disease.60, 62 It will be important to explore both mechanisms in NIID pathogenesis in the future.