Systemic inflammation, podocyte injury, and proteinuria are features of CKD and in which ETA receptor activation plays a key role.13 All 3 have also been shown to increase tissue and circulating PCSK9 expression in mice.11,12 However, there was inconsistent evidence in these studies of a concurrent upregulation of SREBP2 (sterol regulatory element binding protein 2) and HNF1α (hepatic nuclear factor 1α), the principle promoters of PCSK9 expression. The gene discussed is SREBF2; the disease is chronic kidney disease.