The CTLA-4 rs231726 gene is associated with a higher risk of developing IgA nephropathy (Wang et al. 2014), and the CTLA-4 rs231779 gene is associated with proteinuria, podocyte foot process effacement, and advanced mesangial proliferation (Kim et al. 2011). The gene discussed is CTLA4; the disease is IgA glomerulonephritis.