Additionally, the neurotrophic factor insulin-like growth factor 2 (IGF2) exhibited a decrease in the proteomic data (0.410 P24/P12 ratio in muscle) and has been implicated in in a mouse models of motor neuron disease (Allodi et al., 2016; Hedlund et al., 2010; Murray et al., 2015; Zhang et al., 2013). The gene discussed is IGF2; the disease is motor neuron disorder.