For example, the NAD-dependent deacetylase sirtuin-2 (SIRT2) exhibited an increase in the proteomic data (1.330 P24/P12 ratio in nerve) and has been demonstrated to be up-regulated across a number of neurodegenerative disease and injury models (Allodi et al., 2016; Amorim et al., 2015; Graham et al., 2017; Hedlund et al., 2010; Murray et al., 2015; Zhang et al., 2013). Here, SIRT2 is linked to neurodegenerative disease.