Indeed, recent studies reported potentially targetable ROS1, TSC1, AKT1, MTOR, PTEN, PIK3CA, NF1, KDR, ERBB1, NTRK1, IDH1 and FGFR3 DNA variants in PC in the presence or absence of CDC73 mutations, with rationally matched targeted agents (41, 56, 57). Here, PIK3CA is linked to pachyonychia congenita.