Indeed, recent studies reported potentially targetable ROS1, TSC1, AKT1, MTOR, PTEN, PIK3CA, NF1, KDR, ERBB1, NTRK1, IDH1 and FGFR3 DNA variants in PC in the presence or absence of CDC73 mutations, with rationally matched targeted agents (41, 56, 57). This evidence concerns the gene MTOR and pachyonychia congenita.