CD86 and systemic lupus erythematosus: However, LPS-mediated upregulation of CD80, CD86 and HLA-DR expressions of CD1c+DCs were significantly decreased in SLE patients after MSCs transplantation compared to before treatment (Fig. 3q, r); similarly, LPS-induced TNFα produced by CD1c+DCs in SLE PBMCs were also significantly decreased after MSCs transplantation (Fig. 3s), whereas the level of IL-10 showed no significant change after U-MSCT (Fig. 3t).