CD1C and systemic lupus erythematosus: Our findings revealed that the number of CD1c+DCs in PBMCs in SLE patients decreased compared with healthy controls and RA patients (Supplementary Fig. 1), and the number of CD1c+DCs was negatively correlated with the SLEDAI score and LN-related indexes (Fig. 1e, f, g, h, i), indicating the crucial role of this tolerogenic DC subset in the pathogenesis of SLE, especially in patients with renal abnormalities.