CHML and hepatocellular carcinoma: Moreover, in silico analysis of two independent datasets from oncomine (Chen Liver, n = 179 and Wurmbach Liver, n = 45) demonstrated that CHML mRNA levels were significantly higher in HCC compared to their normal counterparts (Fig. 1b), and this pattern could also be seen in TCGA dataset (TCGA, liver cancer data set) (Supplementary Fig. 1a).