Moreover, the removal of TKTL1 by an anti-TKTL1 antibody from TKTL1-overexpressing ccRCC tissues almost depleted TKT levels, whereas the removal of TKTL1 from TKTL1-low expressing, corresponding adjacent normal tissues did not deplete TKT (Fig. 5b). The gene discussed is TKTL1; the disease is nonpapillary renal cell carcinoma.