Recently, FEZF1 has also been implicated in the progression of tumorigenesis, including enhancing the proliferation and tumorigenicity of GC by binding and activating the oncogene K-ras [15], promoting cell migration and invasion of CRC cells [16], playing a carcinogenic role in CC by acting as a transcriptional activating factor in the Wnt pathway [17], facilitating the development of glioma cells by activating Akt-ERK pathway [18], and so on. The gene discussed is FEZF1; the disease is colorectal carcinoma.