FEZF1 and neoplasm: FEZF1-AS1 with relatively high expression in CRC cells was screened for experiments, and it was confirmed that silencing of FEZF1-AS1 could reduce the S phase of CRC cells and increase apoptosis, transwell analysis illustrated that FEZF1-AS1 knockdown inhibited the migration and invasion of CRC cells, and tumor xenograft model in nude mice demonstrated that FEZF1-AS1 overexpression stimulated lung metastasis and liver metastasis of CRC [35].