BZW2 and colorectal carcinoma: Next, we investigated the effect of 5MP1 knockdown in the 5MP1-replete LoVo and RCM1 CRC cell lines (Fig. S3a) with two small interfering RNAs (siRNAs) targeting 5MP1. Both siRNAs targeting 5MP1 strongly reduced 5MP1 expression (Fig. 2h and i; also see Fig. 3e).