Diversely, in NSCLC and NPC cells, NEO212 induced ROS accumulation was the key contributor to its cytotoxicity because it can be reversed by two ROS scavengers, catalase (CAT) and N-acetyl-L-cysteine (NAC); However, NEO212 seemed not alter the level of intracellular ROS accumulation (data not shown), indicating alternative pathway was involved in. Here, CAT is linked to nasopharyngeal carcinoma.