Among the commonly upregulated LD+ associated genes in GBM cells and patient tumors, we found several hypoxia-related, key effectors of angiogenesis, macrophage recruitment and stromal remodeling in cancer (e.g. VEGF-A, TGF-β1, IL1β, ADM, IGFB3, LOX, CA9, THBS1, PLODs, ID2) (Fig. 1g). The gene discussed is CA9; the disease is cancer.