For example, miR-21, miR-125b, miR-181a, miR-196a, and miR-148b suppress the expression of the apoptosis-related genes caspase-3, intercellular adhesion molecule-2 (ICAM-2), Protein Kinase C Delta (PRKCD), annexin A1 (ANXA1), or DNA methyltransferase 3b (DNMT3B) in a wide spectrum of cancers [56]. The gene discussed is ICAM2; the disease is cancer.