Several tau PET studies have shown a close relationship between patterns of tau deposition and atrophy measures [39–41] and recent work has shown memory scores to be strongly correlated with medial temporal tau tracer uptake, whereas whole-brain measures showed weak associations with memory and MTL atrophy, supporting the notion that regional tau measures have greater sensitivity to early neurodegeneration and memory decline compared to global measures of tau [39, 42]. Here, MAPT is linked to Atrophy.