CD274 and metastatic malignant neoplasm in the lymph nodes: In this study, we used a tissue microarray (TMA) including 598 GC primary lesion specimens to investigate the expression of PD-L1 and quantify tumor-infiltrating CD3+, CD8+ T lymphocytes, FOXP3+ Tregs, and CD163+M2 macrophages density to determine their relationships with clinicopathological features and prognosis in GC patients based on different locations, clinicopathological stages, pathological classifications, chemotherapy strategies, and lymph node metastasis.