COMT and 22q11.2 deletion syndrome: Furthermore, several genes from A to D including COMT, PRODH, GNB1L, TBX1, SEPT5/GP1BB, ZDHHC8, PI4KA, and ARVCF have been individually associated with SCZ, ASD, ADHD, and other disorders frequently diagnosed in individuals with 22q11DS [18–20].