Polymorphisms in CXCL10 gene promoter could also contribute to susceptibility to COPD: The “rs56061981” single nucleotide polymorphism (SNP) is significantly associated with a reduced risk of developing COPD, and the “rs56216945” SNP is associated with an increased risk; the implicated mechanism could be an alteration of monocyte recruitment [142]. The gene discussed is CXCL10; the disease is chronic obstructive pulmonary disease.