Activation of the transcription factor Yes-associated protein (YAP) leads to endothelial dysfunction, where the EC junction protein junctional cadherin 5 associated (JCAD) activates YAP pathway, by relieving the tonic inhibitory effects of kinase linker for activation of T cells ( LATs) on YAP, an effect which requires RhoA [36]. Here, JCAD is linked to endothelial dysfunction.