RhoA/Rho-kinase activation has significant effects on various cardiovascular diseases, mainly arterial hypertension, atherosclerosis, heart attack, stroke, and others, such as coronary vasospasm, venous diseases, myocardial hypertrophy, myocardial ischemia-reperfusion injury, and vascular remodeling [10,11]. This evidence concerns the gene RHOA and myocardial ischemia.