A less commonly applied, but highly effective approach to reduce the risk of exercise-induced hypoglycemia faces subcutaneous mini-dose injections of glucagon [9]; in this study Rickels and colleagues showed that 150 mg of glucagon may be more effective than a 50% basal insulin reduction for preventing exercise-induced hypoglycemia and may result in less post-intervention hyperglycemia than a standardized ingestion of 40 g oral glucose tablets. Here, INS is linked to Hypoglycemia.