IGHE and food allergy: Taken together, sophisticated approaches for modeling food allergy in the context of a humanized immune system in mice at hand, enable us to study allergic mechanisms as well as the impact of novel treatment options as is exemplary shown in a publication by Pagovich et al. They tested the efficacy of an adeno-associated virus (AAV)-based transfer of anti-human IgE as possible vaccine in a humanized mouse model of peanut allergy [82].