IGHE and food allergy: Among the mouse models of food allergy, one can distinguish between (1) models that just investigate immune responses towards the applied allergens, such as induction of Th2 responses, IgE and IgG1 production, or mast cell activation and (2) models that also try to recreate the clinical symptoms of the food allergic reaction such as local inflammation in the gut, the mouth, and face, anaphylactic reactions, and behavioral changes (reduced activity).