It is noteworthy that the longitudinal study of the Western Australian Pregnancy Cohort (Raine), involving male children born in 1989–1991 followed from birth until the age of 20 years, has shown that patients with insulin resistance (Homeostatic Model Assessment of Insulin Resistance (HOMA) > 4), probably being hyperinsulinemics, had lower inhibin B and higher FSH levels at the age of 17–20 years, even after adjusting for age, body mass index, abstinence, history of cryptorchidism, varicocele, cigarette smoking, alcohol consumption and drugs (Hart et al., 2019). This evidence concerns the gene BRD2 and Insulin resistance.