TNFAIP3 and Zinc deficiency: Our previous experimental studies have shown that zinc sufficiency increases A20 expression and A20–TRAF1 complex binding, and decreases the generation of inflammatory cytokines and oxidative stress in non-T lymphocyte cells such as (HL-60) human promyelocytic leukemia cell line, (TPH-1) the human monocytic leukemia cell line, and (HUVEC) the human umbilical vein endothelial cells, as compared to zinc deficiency in those cells [7,69,70].