The overexpressed coagulation pathway found in PCOS-FF, characterized by intrinsicand extrinsic prothrombin activation, is also linked to an inflammatory response;this pathway has important roles in follicle physiology (de Agostini, 2006) and may be associated with poor IVF outcomes(Bianchi et al.,2016). Here, F2 is linked to polycystic ovary syndrome.