The maincanonical pathways (Supplemental Table III)found only for the proteins in the FF from the PCOS patients were LXR/RXR activation(p=9.04 E-11, overlap 7%) and FXR/RXR activation(p=1.67 E-10, overlap 6.6%), which are key for themetabolism of lipids, lipoproteins and glucose, reflecting the disrupted metabolismexhibited by PCOS patients. Here, NR1H4 is linked to polycystic ovary syndrome.