Yuan et al recently reported that splicing factor MBNL3 modulated the alternative splicing of lncRNA PXN‐AS1, which generated 2 different isoforms of PXN‐AS1.33 PXN‐AS1‐L is one of the isoforms which contains the exon 4 and has 863 nucleotides in length, and whereas PXN‐AS1‐S is another isoform which lacks the exon 4 and has 686 nucleotides in length.33 They found PXN‐AS1‐L was upregulated in HCC tissues and had oncogenic roles in HCC.33 In this study, we focused our attention on lncRNA PXN‐AS1‐L. This evidence concerns the gene PXN-AS1 and hepatocellular carcinoma.