One important factor that contributes to prognosis is the differences in cytogenetics findings associated with different age groups: for example, a high frequency of favorable cytogenetics groups such as hyperdiploidy and t(12;21)(p13;q22.1)/ETV6‐RUNX1 in children versus a high frequency of unfavorable cytogenetics such as t(11q23;v)/KMT2A in infants and t(9;22)(q34;q11.2)/BCR‐ABL1, hypodiploidy and/or a complex karyotype in adults.1 Studies have shown that age itself might not be a significant prognostic factor in adult B‐ALL, but the presence of unfavorable cytogenetics.10 The gene discussed is RUNX1; the disease is precursor B-cell acute lymphoblastic leukemia.