Anorexia nervosa is a disorder associated with alterations in hormonal profiles.2,3,35 Reduced serum concentrations of estradiol and insulin-like growth factor 1 together with decreased lifetime exposure to estrogens owing to delayed puberty and hastened menopause might partially explain why young women with anorexia nervosa may have reduced risk of breast cancer and other hormone-sensitive tissue cancers. The gene discussed is IGF1; the disease is anorexia nervosa.