Regardless of whether the fragment in CTF2 or CTF3, the result of DECMA-1 increasing proteolysis of endogenous E-cadherin in a relevant cancer cell line not only provides validation of using the SNAPS assay to study proteolysis in diverse receptors but also provides new mechanistic insight into how DECMA-1 functionally disrupts cell to cell adhesion. Here, CEBPZ is linked to cancer.