Moreover, high levels of MMPs and thus dystroglycan cleavage have been observed in muscle biopsies of muscular dystrophy patients (Matsumura et al., 2005), and treatment of muscular dystrophy mouse models with broad spectrum metalloprotease inhibitors has been shown to ameliorate symptoms in a muscular dystrophy mouse model (Kumar et al., 2010). This evidence concerns the gene DAG1 and muscular dystrophy.