This appears to be explained by the impact of immunosuppression (corticosteroids or azathioprine) which significantly lowered ICAM-1 levels regardless of the presence of severity of colitis (476,865 ± 126,033 pg/ml in patients on immunosuppression versus 805,914 ± 191,230 pg/ml in other patients, p = 0.02; Fig. 5e). The gene discussed is ICAM1; the disease is colitis.