TNFRSF11B and posterior cortical atrophy: In PCa skeletal metastasis animal models, we and others have demonstrated anti-resorptive agents such as soluble receptor activator of NF-kappaB (sRANK) (Zhang et al. 2003), osteoprotegerin (OPG) (Zhang et al. 2001), and overexpression of OPG successfully diminished the tumor growth in bone (Corey et al. 2005).