In PCa skeletal metastasis animal models, we and others have demonstrated anti-resorptive agents such as soluble receptor activator of NF-kappaB (sRANK) (Zhang et al. 2003), osteoprotegerin (OPG) (Zhang et al. 2001), and overexpression of OPG successfully diminished the tumor growth in bone (Corey et al. 2005). This evidence concerns the gene TNFRSF11B and neoplasm.