This characterization is further supported by mutations in MFRP in different families with nanophthalmos (Sundin et al. 2005), high hyperopia (Xu et al. 2016), or posterior microphthalmia (Aldahmesh et al. 2011; Matsushita et al. 2012; Wasmann et al. 2014). Here, MFRP is linked to microphthalmia.