The role of MMP-9 in the development of epilepsy has been also supported by studies with such models of epilepsy as treatment with either pilocarpine or 4-aminopyridine (seizure-inducing drugs), as well as the use of Wistar Albino Glaxo Rijswijk (WAG/Rij) rats that display higher propensity for seizure activity [156, 157]. This evidence concerns the gene MMP9 and epilepsy.