ERBB2 and breast cancer: Furthermore, we identified that lack of Sfrp3 in MMTV-Neu animals induces a significative reduction in the time of appearance of mammary tumours (from an estimated median of 405 days in Srrp3+/− animals to 344 days in Sfrp3−/− mice; p = 0.0148) (Fig. 7f), suggesting a role for Sfrp3 as relevant marker for BC susceptibility.