We observed that the expression of 8 genes (Slc1a2, Larp1b, Lef1, Edn2, Slc6a12, Fgf21, C1qtnf5 and Flt3l) is appreciably elevated in invasive BC compared to normal breast samples using the Cancer Genome Atlas (TCGA) dataset (Fig. 7b). This evidence concerns the gene EDN2 and breast cancer.