Although it may eventually be possible to reproduce the full range of premature tauopathy-like phenotypes found in rTg4510 by using targeted genomic modifications to generate control lines that more precisely and reproducibly generate the confounding contributions from the Fgf14-TgINDEL mutation (e.g., similar Fgf14 dysregulation), this would be a new experimental system, and key findings from rTg4510 would need to be reproduced in this new system. The gene discussed is FGF14; the disease is tauopathy.