If nothing else, the unique tTA expression pattern generated from the combination of the CamKII promoter fragment within the context of the Vipr2-Ptprn2 tTA-TgINDEL mutation defines the tauP301L expression pattern in rTg4510, and likely defines the tissue specificity of the tauopathy phenocopy as well. The gene discussed is PTPRN2; the disease is tauopathy.