For more than a decade rTg4510 mice have been widely used as a model of human tauopathy but without recognizing the necessary confounding contributions from the Fgf14 tauP301L-TgINDEL, and with only recent and inconsistent attempts to control for the contributions from the previously undefined Vipr2-Ptprn2 tTA-TgINDEL allele13. Here, FGF14 is linked to tauopathy.