GGPS1 and male infertility: Based on our previous study of patients with male infertility who had been infected with the mumps virus before puberty, geranylgeranyl diphosphate synthase (Ggpps) deficiency in the SCs could induce excessive cytokine and chemokine synthesis, and result in the invasion of macrophage into seminiferous tubule during puberty when BTB was not completely formed.