PTP4A3 and neoplasm: Likewise, we reasoned that the upregulation of PRL3 surface+ population was greater in tumor cells (57-fold; Fig. 2f) compared to serum-starved cultured cells (8.4-fold; Fig. 2g) likely due to the additional stresses faced within the tumor microenvironment, such as hypoxia or pH stress, which might further exacerbate PRL3 surface relocalization.