Restoration of miR-708 inhibited cell growth and the epithelial-to-mesenchymal transition (EMT) phenotype in glioma, and suppression of the sphingosine kinase 2 (SPHK2)/AKT/β-catenin pathway might be a critical function of miR-708 in glioma. This evidence concerns the gene AKT1 and central nervous system cancer.