Enhancer of zeste homolog 2 (EZH2), a methyltransferase and the core catalytic element of the polycomb-repressive complex 2 (PRC2), can induce genome-wide histone H3 lysine 27 trimethylation (H3K27me3) and acts as an oncogene by repressing tumor suppressor genes in cancers23,24. The gene discussed is EZH2; the disease is neoplasm.