In order to further elucidate the functional and mechanistic consequences of TGFβ signaling in the context of constitutively active NFATc1 we isolated primary PDAC cells from three different tumor-bearing NKC p48 mice (further designated as NKC-II, NKC-VI, and NKC-VIII) (Fig. 1b). Here, TGFB1 is linked to neoplasm.