GPT and fatty liver disease: Moreover, overexpression of IGF-1 with lentiviral vector attenuated the content of serum glutamic pyruvic transaminase (ALT) on Day 6 and Day 28 and relieved CCl4-induced hepatic steatosis and fibrogenesis (Fig. 2b–e), confirming alleviation of CCl4-induced acute and chronic liver injury by overexpressing IGF-1.