Moreover, serving as an index of myocardial injury [20], the increased level of serum creatine phosphokinase (CPK) in mice subjected to MI/R injury was also considerably reduced when cardiac TRIM6 was depleted (Figure 2D), together indicating that TRIM6 knockdown in the heart ameliorates MI/R injury. The gene discussed is PIK3C2A; the disease is myocardial infarction.