In contrast, TRIM6 overexpression in the heart of MI/R mice increased the number of TUNEL positive cardiomyocytes (Figure 3D) and elevated the caspase 3 activity (Figure 3E) and expression of cleaved caspase-3 (Supplementary Figure 2B), and Bax/Bcl-2 ratio (Figure 3F). The gene discussed is BAX; the disease is myocardial infarction.