PIK3C2A and myocardial infarction: We found that the treatment of both CAY10576 and fludarabine reversed TRIM6-aggravated myocardial infarct size (Figure 5A) and serum CPK level (Figure 5B), therefore illustrating that TRIM6 promotes MI/R injury by inducing IKKε/STAT1 activation-mediated myocardial apoptosis.