Peroxynitrite production was investigated in vestibular schwannomas (VS) from NF2 patients, human and mouse wildtype (WT) Schwann cells, as well as in human and mouse Schwann cells deficient in merlin expression either by merlin knockdown, or by merlin knockout as a result of NF2 exon 2 deletion (34, 35). Here, NF2 is linked to Vestibular schwannoma.