Anti-CCP–positive RA was found associated with HLA-DRB1, HLA-DP, PTPN22, C5-TRAF1, and TNFAIP3-OLIG3 polymorphisms [11–13], whereas anti-CCP–negative RA was found associated with genes such as HLA-DR3 and IRF-5 [13, 14], two genes that are also associated with systemic lupus erythematosus and Sjögren syndrome. This evidence concerns the gene C5 and rheumatoid arthritis.