In summary, our results suggested that lncRNA DLX6-AS1 could serve as an oncogene in LCSCs by which silenced DLX6-AS1 contributes to decrease of the methylation of CADM1 promoter and inactivation of the STAT3 signaling pathway, thus exerting suppressive effects on tumorigenesis and tumor development of LCSCs (Fig. 8). Here, CADM1 is linked to neoplasm.