STAT3 and neoplasm: In summary, our results suggested that lncRNA DLX6-AS1 could serve as an oncogene in LCSCs by which silenced DLX6-AS1 contributes to decrease of the methylation of CADM1 promoter and inactivation of the STAT3 signaling pathway, thus exerting suppressive effects on tumorigenesis and tumor development of LCSCs (Fig. 8).