Previously, it has been proposed that CD25 is a surrogate marker for leukemia stem cell (LSC) [4, 5], our results again provided evidence that IL2RA/CD25 is involved in the crosstalk of LSC related signalling and support that IL2RA is an indicator of the LSC signature which has been shown as a fundamental adverse prognostic feature in AML [59]. This evidence concerns the gene IL2RA and acute myeloid leukemia.