The major discoveries were (1) CD68+ TAMs were associated with decreased rates of recurrent and multifocal disease; (2) conversely, M2-polarized TAMs correlated with lymphangiosis carcinomatosa and multifocal HCC; (3) TILs and infiltrating CD68+ TAMs were strongly associated in HCC; and (4) had a potent influence on recurrence-free survival. The gene discussed is CD68; the disease is hepatocellular carcinoma.