In pancreatic cancer, hypoxic pancreatic stellate cells (PSCs) high expression of PLOD2 to promote cancer cell motility through alteration of extracellular matrix (ECM) fiber architecture, while knockdown of PLOD2 in PSCs blocked parallel fiber architecture of matrices, leading to decreased directional migration of cancer cells within the matrices [36]. This evidence concerns the gene PLOD2 and familial pancreatic carcinoma.