In addition, as FOXA1 plays a critical role in driving PLOD2 transcription expression in NSCLC [19], we also detected the role of FOXA1 in regulating PLOD2 in CAAs, and the results showed that the expression of FOXA1 was extremely low in adipocytes and was not consistently altered upon coculturing with different breast cancer cells (Additional file 5: Figure S3D). This evidence concerns the gene FOXA1 and breast cancer.