PLOD2 and breast cancer: In vivo subcutaneously adipose tissue and breast cancer cells co-injection metastatic model further confirmed the peritumoral adipose-derived collagen reorganization and PLOD2 was activated in adipocytes at the invasive front of breast cancer, adipose-breast cancer cells co-injection promoted tumor cells far away spread to lungs, while inhibition of PLOD2 inhibited breast cancer metastasis (Fig. 2 and Fig. 4).