TIMP1 and liver dysplastic nodule: Finally, the Tang-Wei-Kang pills, made of extract from Astragalus, hirudo, and Schisandra chinensis, are known to have a positive effect on patients with DN [7, 8], up-regulating the expression of Matrix metallopeptidase 9 (MMP-9), while down-regulating the expression of TIMP metallopeptidase inhibitor 1 (TIMP-1) in the kidneys of DN rat models [8, 9].