PCA3 and Familial prostate cancer: Some of these genes were already extensively studied in prostate cancer, mostly those upregulated in tumor tissue: SPINK1 [14] (Top17, logFC 4.8), ETV4 [15] (Top63, logFC 3.6), PCA3 [9] (Top79, logFC 3.5), TDRD1 [16, 17] (Top86, logFC 3.4), AMACR [18] (Top105, logFC 3.2), DLX1 [10] (Top110, logFC 3.1), HOXC6 [10] (Top268, logFC 2.3).