In addition, activation of TLR9 has been shown to be integral to the development of vascular dysfunction in hypertension, heart failure secondary to myocarditis and liver fibrosis in animal models [11–13] suggesting that TLR9 signaling plays a role in mediating pathologic responses to released mtDNA as a danger-associated molecular patterns (DAMPs). This evidence concerns the gene TLR9 and Hypertension.