For example, FPR2/ALX has demonstrated to be a functional receptor for prion protein fragment PrP106-126, as well as the amyloidogenic peptides serum amyloid A and amyloid-β; which play important roles in the neurodegenerative activity of Alzheimer’s disease (AD) and prion diseases [17,18,19]. Here, FPR2 is linked to early-onset autosomal dominant Alzheimer disease.